KMID : 0617319910010010060
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Journal of Pharmacetical Sceiences Ewha Womans University 1991 Volume.1 No. 1 p.60 ~ p.66
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Synthesis of Anticoagulant 3-(N-Arylamino)-1,4-Naphthoquinones(¥²)
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Abstract
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2.3-Dibromo-1.4-naphthoquinone was reacted with p-aminobenzoic acid. 2-aminopyridine, 2-amino-4-metylpyridine, m-nitroaniline, sulfathiazol, p-chloroaniline, phenetidine and 2-bromo-3-(N-aryl-amino)-1.4-naphthoquinones (1~8)
2.3-Epoxy-2.3-dihydro-1.4-naphthoquinone was also reacted with p-amonobenzoic acid, p-toluidine, p-chloroaniline, m-chloroaniline, m-nitroaniline, p-phenetidine, N, N-dimethyl-1.4-pheylenediamine as a ring opening and dehydogenation to form 2-hydroxy-3-(N-arylamino)-naphthoquinones ((~16) in good yield.
These new compounds (1~16) are expected to have a biological activities such as anticoagulant and cytotoxic.
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KEYWORD
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